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How should I take TAFINLAR + MEKINIST?

As you begin your treatment for BRAF V600E metastatic NSCLC, it's important that you keep a list of all of your medicines and show it to your health care provider whenever you begin taking a new medicine. Certain medicines may affect each other, causing side effects. It’s also important to develop a routine around taking your medication, so it becomes second nature.
 

Recommended dosing for TAFINLAR + MEKINIST


Note: Take your medication either 1 hour before or 2 hours after eating. The recommended daily dose of TAFINLAR is 150 mg twice daily. Be sure to take doses 12 hours apart. The recommended daily dose of MEKINIST is 2 mg by mouth. Take MEKINIST at the same time each day—either with your morning or evening dose of TAFINLAR. 

How should I take TAFINLAR?
  • Take TAFINLAR exactly as your health care provider tells you. Do not change your dose or stop TAFINLAR unless your health care provider tells you

  • Your health care provider may change your dose of TAFINLAR, temporarily stop, or completely stop your treatment with TAFINLAR if you develop certain side effects 

  • Take TAFINLAR 2 times a day, about 12 hours apart

  • Take TAFINLAR at least 1 hour before or 2 hours after a meal

  • Do not open, crush, or break TAFINLAR capsules

  • If you miss a dose of TAFINLAR, take it as soon as you remember. But if it is within 6 hours of your next scheduled dose, just take your next dose at your regular time. Do not make up for the missed dose


How should I take MEKINIST?
  • Take MEKINIST exactly as your health care provider tells you to take it. Do not change your dose or stop MEKINIST unless your health care provider tells you

  • Your health care provider may change your dose of MEKINIST, temporarily stop, or completely stop your treatment with MEKINIST if you develop certain side effects

  • Take MEKINIST one time a day, about every 24 hours

  • Take MEKINIST at least 1 hour before or 2 hours after a meal

  • If you miss a dose, take it as soon as you remember. If it is less than 12 hours before your next scheduled dose, skip the missed dose. Just take the next dose at your regular time

It is important that you understand and follow your health care provider’s directions for taking TAFINLAR + MEKINIST. Do not change your dose or stop TAFINLAR or MEKINIST, unless your health care provider tells you to.

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Keep TAFINLAR, MEKINIST, and all medicines out of the reach of children.

Important Safety Information

TAFINLAR and MEKINIST may cause serious side effects, including:

Risk of new cancers. TAFINLAR, when used in combination with MEKINIST, may cause a type of skin cancer called cutaneous squamous cell carcinoma, keratoacanthoma, basal cell carcinoma, or melanoma. Talk with your health care provider about your risk for these cancers. Check your skin and tell your health care provider right away about any skin changes, including a new wart, skin sore, or reddish bump that bleeds or does not heal, or a change in size or color of a mole.

Your health care provider should check your skin before you start treatment, and every 2 months while on treatment, to look for any new skin cancers. Your health care provider should continue to check your skin for 6 months after you stop taking TAFINLAR and MEKINIST.

Approved Uses

TAFINLAR and MEKINIST are prescription medicines that can be used in combination to treat people with a type of skin cancer called melanoma:

  • that has spread to other parts of the body (metastatic) or cannot be removed by surgery (unresectable), and

  • that has a certain type of abnormal “BRAF” (V600E or V600K mutation-positive) gene

TAFINLAR and MEKINIST are prescription medicines that can be used in combination to help prevent melanoma that has a certain type of abnormal “BRAF” gene from coming back after the cancer has been removed by surgery.

Click or scroll to see IMPORTANT SAFETY INFORMATION AND APPROVED USES