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Side effects of TAFINLAR + MEKINIST

Serious side effects
As with many medications, you may experience some side effects while taking TAFINLAR + MEKINIST in combination. Below are possible side effects of treatment.

Taking TAFINLAR + MEKINIST may cause serious side effects, including:

New skin cancers icon


New skin cancers, including cutaneous squamous cell carcinoma, keratoacanthoma, basal cell carcinoma, or melanoma 

Bleeding problems icon


Bleeding problems

Inflammation of intestines icon


Inflammation of the intestines or tears (perforation) of the stomach or intestines

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Blood clots

Heart problems icon


Heart problems, including heart failure 

Eye problems icon


Eye problems 

Lung problems icon


Lung or breathing problems 

Fever icon


Fever

Serious skin reactions icon


Serious skin reactions

Increased blood sugar icon


Increased blood sugar (hyperglycemia) 

Healthy red blood cells breaking down too soon icon


Healthy red blood cells to break down too early in people with glucose-6-phosphate dehydrogenase deficiency 

Worsening blood pressure icon


New or worsening high blood pressure (hypertension) 

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May increase the risk of a type of overactivity of the immune system (hemophagocytic lymphohistiocytosis) that can cause fever, swollen glands, bruising, or skin rash 

Low sperm counts icon


Low sperm counts 

Ferility problems icon


Fertility problems 

 

The most common side effects of TAFINLAR, in combination with MEKINIST, when used in patients with NSCLC include:

Fever icon


Fever

Tiredness icon


Tiredness

Nausea icon


Nausea

Vomiting icon


Vomiting

Diarrhea icon


Diarrhea (call your health care provider if you get severe diarrhea)

Dry skin icon


Dry skin

Decreased appetite icon


Decreased appetite 

Rash icon


Rash

Swelling icon


Swelling of the face, arms, and legs

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Chills

Bleeding problems icon


Bleeding

Cough icon


 Cough

Shortness of breath icon


Shortness of breath 

 

 

Talk to your health care provider about your side effects. These are not all the possible side effects of TAFINLAR + MEKINIST. Be sure to tell your health care provider about how you’re feeling or if you have any concerns about your treatment.

Important Safety Information

TAFINLAR and MEKINIST may cause serious side effects, including:

Risk of new cancers. TAFINLAR, when used in combination with MEKINIST, may cause a type of skin cancer called cutaneous squamous cell carcinoma, keratoacanthoma, basal cell carcinoma, or melanoma. Talk with your health care provider about your risk for these cancers. Check your skin and tell your health care provider right away about any skin changes, including a new wart, skin sore, or reddish bump that bleeds or does not heal, or a change in size or color of a mole.

Your health care provider should check your skin before you start treatment, and every 2 months while on treatment, to look for any new skin cancers. Your health care provider should continue to check your skin for 6 months after you stop taking TAFINLAR and MEKINIST.

Approved Uses

TAFINLAR and MEKINIST are prescription medicines that can be used in combination to treat people with a type of skin cancer called melanoma:

  • that has spread to other parts of the body (metastatic) or cannot be removed by surgery (unresectable), and

  • that has a certain type of abnormal “BRAF” (V600E or V600K mutation-positive) gene

TAFINLAR and MEKINIST are prescription medicines that can be used in combination to help prevent melanoma that has a certain type of abnormal “BRAF” gene from coming back after the cancer has been removed by surgery.

Click or scroll to see IMPORTANT SAFETY INFORMATION AND APPROVED USES